Epidemiology, Clinical Manifestations, and Long-Term Outcomes of a Major Outbreak of Chikungunya in a Hamlet in Sri Lanka, in 2007 : A Longitudinal Cohort Study

Abstract EN

Chikungunya outbreaks occurred in the central province, Sri Lanka in 2006.

This community-based study reports the epidemiology and the natural history of the infection from an affected village.

Of the 199 families and 1001 individuals in the village, 159 (80%) and 513 (51%) were affected, respectively, comprising 237 (46%) males with peak incidence at 40–50 years.

The acute illness caused polyarthritis in 233 (46%), and of them 230 (98%) progressed to chronic arthritic disability (CAD).

Of the CAD patients, 102 (44%) had recovered in 141 days (range 30–210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively.

Carpal tunnel syndrome (CTS) manifested in 110 (21%).

Females showed preponderance for complications over males: acute arthritis 147 versus 86, P=0.001; CAD 136 versus 84, P=0.029; CTS 88 versus 22, P=0.001; relapses 105 versus 68, P=0.001.

Chikungunya was highly communicable and caused lasting crippling complications.