Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats
Joint Authors
Montero, Mercedes
Navarro, Daisy
Martín-Fernández, Marta
Rubert, Mercedes
Guede, David
de la Piedra, Concepción
Caeiro, Jose Ramón
Diaz Curiel, Manuel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We studied the ability of Kalsis, a food supplement that contains selenium, citric acid, and vitamin E, to prevent the effects of ovariectomy on bone loss.
Six-month-old, Wistar female rats were studied.
Groups (n=12): SHAM: sham-operated rats; OVX: ovariectomized rats, treated with vehicle; OVX + Kalsis: ovariectomized rats treated with Kalsis (25 mg/kg/day) for 3 months.
Bone mineral density (BMD) was determined by DXA in lumbar spine and femur.
Computerized microtomography (μCT) in femur and serum osteocalcin (BGP), aminoterminal propeptide of procollagen I (PINP), β-isomer of carboxyterminal telopeptide of collagen I (CTX), and 5b isoenzyme of tartrate-resistant acid phosphatase (TRAP) were performed.
Treatment with Kalsis prevented BMD loss in OVX group.
μCT showed a decrease in BV/TV, and trabecular number, and an increase in trabecular separation in OVX rats.
Kalsis administration attenuated partially bone loss observed by μCT due to ovariectomy.
BGP, PINP, and the resorption index (CTX/TRAP) were increased in OVX group.
Treatment with Kalsis maintained this increase.
The mechanism of action of this supplement is not through a decrease in bone remodelling rate.
The antioxidant action of this food supplement, due to the synergism of all its components, as a cause of its beneficial effect is suggested.
American Psychological Association (APA)
Montero, Mercedes& Diaz Curiel, Manuel& Guede, David& Caeiro, Jose Ramón& Martín-Fernández, Marta& Rubert, Mercedes…[et al.]. 2012. Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats. Journal of Osteoporosis،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-487335
Modern Language Association (MLA)
Montero, Mercedes…[et al.]. Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats. Journal of Osteoporosis No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-487335
American Medical Association (AMA)
Montero, Mercedes& Diaz Curiel, Manuel& Guede, David& Caeiro, Jose Ramón& Martín-Fernández, Marta& Rubert, Mercedes…[et al.]. Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats. Journal of Osteoporosis. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-487335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487335