The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth
Joint Authors
Alitheen, Noorjahan Banu Mohamed
Rathnavelu, Vidhya
Subramani, Tamilselvan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gingival overgrowth is a side effect of certain medications.
The most fibrotic drug-induced lesions develop in response to therapy with phenytoin, the least fibrotic lesions are caused by cyclosporin A, and the intermediate fibrosis occurs in nifedipine-induced gingival overgrowth.
Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent tissue repair program.
During connective tissue repair, activated gingival fibroblasts synthesize and remodel newly created extracellular matrix.
Proteins such as transforming growth factor (TGF), endothelin-1 (ET-1), angiotensin II (Ang II), connective tissue growth factor (CCN2/CTGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF) appear to act in a network that contributes to the development of gingival fibrosis.
Since inflammation is the prerequisite for gingival overgrowth, mast cells and its protease enzymes also play a vital role in the pathogenesis of gingival fibrosis.
Drugs targeting these proteins are currently under consideration as antifibrotic treatments.
This review summarizes recent observations concerning the contribution of TGF-β, CTGF, IGF, PDGF, ET-1, Ang II, and mast cell chymase and tryptase enzymes to fibroblast activation in gingival fibrosis and the potential utility of agents blocking these proteins in affecting the outcome of drug-induced gingival overgrowth.
American Psychological Association (APA)
Subramani, Tamilselvan& Rathnavelu, Vidhya& Alitheen, Noorjahan Banu Mohamed. 2013. The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-487340
Modern Language Association (MLA)
Subramani, Tamilselvan…[et al.]. The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-487340
American Medical Association (AMA)
Subramani, Tamilselvan& Rathnavelu, Vidhya& Alitheen, Noorjahan Banu Mohamed. The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-487340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487340