New Aspects in the Differential Diagnosis and Therapy of Bladder Pain SyndromeInterstitial Cystitis
Joint Authors
Schwalenberg, Thilo
Neuhaus, Jochen
Horn, Lars-Christian
Alexander, Henry
Stolzenburg, Jens-Uwe
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC) is presently based on mainly clinical symptoms.
BPS/IC can be considered as a worst-case scenario of bladder overactivity of unknown origin, including bladder pain.
Usually, patients are partially or completely resistant to anticholinergic therapy, and therapeutical options are especially restricted in case of BPS/IC.
Therefore, early detection of patients prone to develop BPS/IC symptoms is essential for successful therapy.
We propose extended diagnostics including molecular markers.
Differential diagnosis should be based on three diagnostical “columns”: (i) clinical diagnostics, (ii) histopathology, and (iii) molecular diagnostics.
Analysis of molecular alterations of receptor expression in detrusor smooth muscle cells and urothelial integrity is necessary to develop patient-tailored therapeutical concepts.
Although more research is needed to elucidate the pathomechanisms involved, extended BPS/IC diagnostics could already be integrated into routine patient care, allowing evidence-based pharmacotherapy of patients with idiopathic bladder overactivity and BPS/IC.
American Psychological Association (APA)
Neuhaus, Jochen& Schwalenberg, Thilo& Horn, Lars-Christian& Alexander, Henry& Stolzenburg, Jens-Uwe. 2011. New Aspects in the Differential Diagnosis and Therapy of Bladder Pain SyndromeInterstitial Cystitis. Advances in Urology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487343
Modern Language Association (MLA)
Neuhaus, Jochen…[et al.]. New Aspects in the Differential Diagnosis and Therapy of Bladder Pain SyndromeInterstitial Cystitis. Advances in Urology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-487343
American Medical Association (AMA)
Neuhaus, Jochen& Schwalenberg, Thilo& Horn, Lars-Christian& Alexander, Henry& Stolzenburg, Jens-Uwe. New Aspects in the Differential Diagnosis and Therapy of Bladder Pain SyndromeInterstitial Cystitis. Advances in Urology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487343