Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups
Joint Authors
Simovart, Helle Evi
Lieberg, Jüri
Aunapuu, Marina
Arend, Andres
Source
International Journal of Vascular Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study aimed at detecting apoptotic endothelial cells (ECs) and smooth muscle cells (SMCs) together with determining expression of NF-kappaB (p105/p50) and Bax in varicose vein walls.
Women (n=35) undergoing the excision of varicose veins were divided into 3 groups: younger than 35 years (I), 36–50 years (II), and older than 50 years (III).
Apoptosis was determined by the TUNEL method, NF-kappaB and Bax expression by immunohistochemistry.
The percentage of apoptotic ECs and SMCs in the layers of varicose vein wall increased in groups II and III.
NF-kappaB expression had the lowest level in Group II with particularly low level in the media.
Contrariwise, Bax expression levels in Group II were increased.
The study revealed that in varicose veins ECs and SMCs apoptosis increased with advancing age.
If increase in apoptosis during earlier stages of varicosities is probably regulated by intrinsic pathway, then in older patients other signaling pathways may be involved.
American Psychological Association (APA)
Simovart, Helle Evi& Arend, Andres& Lieberg, Jüri& Aunapuu, Marina. 2011. Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups. International Journal of Vascular Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487364
Modern Language Association (MLA)
Simovart, Helle Evi…[et al.]. Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups. International Journal of Vascular Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-487364
American Medical Association (AMA)
Simovart, Helle Evi& Arend, Andres& Lieberg, Jüri& Aunapuu, Marina. Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups. International Journal of Vascular Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487364