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Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus
Joint Authors
Pretto, Guilherme Gonçalves
Edelweiss, Maria Isabel Albano
Mazzini, Guilherme da Silva
Meurer, Luise
Gurski, Richard Ricachenevsky
Volkweis, Bernardo Silveira
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett’s esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression.
Methods.
Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett’s esophagus, esophageal adenocarcinoma, and controls.
We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control).
Results.
In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race.
Patients with cancer were predominantly men.
The Ki-67 index averaged 10±4 % in patients with normal gastric mucosa (n=17), 21±15 % in patients with Barrett’s esophagus (n=21), and 38±16 % in patients with cancer (n=19).
Ki-67 expression was significantly different between all groups (P<0.05).
There was a strong linear correlation between Ki-67 expression and the metaplasia-adenocarcinoma sequence (P<0.01).
In patients with cancer, Ki-67 was not associated with clinical or surgical staging.
Conclusions.
Ki-67 antigen has increased expression along the metaplasia-adenocarcinoma sequence.
There is a strong linear correlation between Ki-67 proliferative activity and Barrett’s carcinogenesis.
American Psychological Association (APA)
Volkweis, Bernardo Silveira& Gurski, Richard Ricachenevsky& Meurer, Luise& Pretto, Guilherme Gonçalves& Mazzini, Guilherme da Silva& Edelweiss, Maria Isabel Albano. 2012. Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487366
Modern Language Association (MLA)
Volkweis, Bernardo Silveira…[et al.]. Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus. Gastroenterology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487366
American Medical Association (AMA)
Volkweis, Bernardo Silveira& Gurski, Richard Ricachenevsky& Meurer, Luise& Pretto, Guilherme Gonçalves& Mazzini, Guilherme da Silva& Edelweiss, Maria Isabel Albano. Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487366