Selective Th2 Upregulation by Crocus sativus : A Neutraceutical Spice
Joint Authors
Bani, Sarang
Pandey, Anjali
Singh, Bikram
Agnihotri, Vijai K.
Pathania, Vijaylata
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The immunomodulatory activity of an Indian neutraceutical spice, saffron (Crocus sativus) was studied on Th1 and Th2 limbs of the immune system.
Oral administration of alcoholic extract of Crocus sativus (ACS) at graded dose levels from 1.56–50 mg/kg p.o.
potentiated the Th2 response of humoral immunity causing the significant increases in agglutinating antibody titre in mice at a dose of 6.25 mg/kg and an elevation of CD19+ B cells and IL-4 cytokine, a signature cytokine of Th2 pathway.
Appreciable elevation in levels of IgG-1 and IgM antibodies of the primary and secondary immune response was observed.
However, ACS showed no appreciable expression of the Th1 cytokines IL-2 (growth factor for CD4+ T cells) and IFN-γ (signature cytokine of Th1 response).
A significant modulation of immune reactivity was observed in all the animal models used.
This paper represents the selective upregulation of the Th2 response of the test material and suggests its use for subsequent selective Th2 immunomodulation.
American Psychological Association (APA)
Bani, Sarang& Pandey, Anjali& Agnihotri, Vijai K.& Pathania, Vijaylata& Singh, Bikram. 2010. Selective Th2 Upregulation by Crocus sativus : A Neutraceutical Spice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487377
Modern Language Association (MLA)
Bani, Sarang…[et al.]. Selective Th2 Upregulation by Crocus sativus : A Neutraceutical Spice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-487377
American Medical Association (AMA)
Bani, Sarang& Pandey, Anjali& Agnihotri, Vijai K.& Pathania, Vijaylata& Singh, Bikram. Selective Th2 Upregulation by Crocus sativus : A Neutraceutical Spice. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487377