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Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection
Joint Authors
Proverbio, Daniela
Spada, Eva
Perego, Roberta
Bagnagatti de Giorgi, Giada
Source
Case Reports in Veterinary Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Two dogs, with naturally acquired canine leishmaniasis, were treated orally with miltefosine (2 mg/kg q 24 hr) and allopurinol (10 mg/kg q 12 hr) for 28 days.
Both dogs showed good initial response to therapy, with reduction in clinical signs and improvement of clinicopathological changes.
However, in both dogs, clinical and clinicopathological abnormalities recurred 150 days after initial treatment and a second course of miltefosine and allopurinol was administered.
One dog failed to respond to the 2nd cycle of miltefosine treatment and the other dog responded initially but suffered an early relapse.
Treatment with meglumine antimoniate (100 mg/kg q 24 hr for a minimum of 4 weeks) was then started in both dogs.
Both dogs showed rapid clinical and clinicopathological improvement and to date they have not received further treatment for 420 and 270 days, respectively.
In view of the low number of antileishmanial drugs available and the fact that some of these are used in human as well as veterinary medicine, it is of paramount importance that drug resistance is monitored and documented.
American Psychological Association (APA)
Proverbio, Daniela& Spada, Eva& Bagnagatti de Giorgi, Giada& Perego, Roberta. 2014. Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection. Case Reports in Veterinary Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-487386
Modern Language Association (MLA)
Proverbio, Daniela…[et al.]. Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection. Case Reports in Veterinary Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-487386
American Medical Association (AMA)
Proverbio, Daniela& Spada, Eva& Bagnagatti de Giorgi, Giada& Perego, Roberta. Failure of Miltefosine Treatment in Two Dogs with Natural Leishmania infantum Infection. Case Reports in Veterinary Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-487386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487386