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T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections
Joint Authors
Van Vooren, Jean-Paul
Bourreau, Eliane
Drowart, Annie
Couppie, Pierre
Farber, Claire-Michèle
Huygen, Kris
Launois, Pascal
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients.
Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria.
Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group.
Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85.
A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.
American Psychological Association (APA)
Launois, Pascal& Drowart, Annie& Bourreau, Eliane& Couppie, Pierre& Farber, Claire-Michèle& Van Vooren, Jean-Paul…[et al.]. 2010. T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-487399
Modern Language Association (MLA)
Launois, Pascal…[et al.]. T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections. Clinical and Developmental Immunology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-487399
American Medical Association (AMA)
Launois, Pascal& Drowart, Annie& Bourreau, Eliane& Couppie, Pierre& Farber, Claire-Michèle& Van Vooren, Jean-Paul…[et al.]. T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-487399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487399