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Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms : A Prospective Cohort Study
Joint Authors
Alexander, David A.
Hutchison, James D.
Sutherland, Alasdair George
Cameron, Gary A.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Posttraumatic psychopathology (PTP) describes the spectrum of conditions that can complicate the recovery from commonly occurring musculoskeletal trauma.
There is a clear association with the activation of the hypothalamic-pituitary-adrenal axis (HPAA), and we wished to examine the predictive value of proinflammatory markers of the HPAA and of the GABA, which acts as an inhibitory regulator.
Methods.
Levels of proinflammatory markers and GABA were measured in 84 patients who had suffered musculoskeletal injuries requiring hospitalisation.
PTP was assessed by the use of the General Health Questionnaire (GHQ) at presentation and again at two- and six-month reviews.
Results.
Significant psychological disturbance was noted in 39% of patients at two months and falling back to 18% by six months.
There was no correlation between any of the markers tested at presentation and PTP at follow-up.
Discussion.
The HPAA response to trauma and the development of PTP are extremely complex.
It is unlikely that a simple blood assay will provide significant predictive information, while incident specific information and patient perception are of more practical use.
American Psychological Association (APA)
Sutherland, Alasdair George& Cameron, Gary A.& Alexander, David A.& Hutchison, James D.. 2008. Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms : A Prospective Cohort Study. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-487438
Modern Language Association (MLA)
Sutherland, Alasdair George…[et al.]. Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms : A Prospective Cohort Study. Mediators of Inflammation No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-487438
American Medical Association (AMA)
Sutherland, Alasdair George& Cameron, Gary A.& Alexander, David A.& Hutchison, James D.. Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms : A Prospective Cohort Study. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-487438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487438