Obesity and Metabolic Comorbidities : Environmental Diseases?
Joint Authors
Lubrano, Carla
Specchia, Palma
Costantini, Daniela
Genovesi, Giuseppe
Mariani, Stefania
Gnessi, Lucio
Lenzi, Andrea
Petrangeli, Elisa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Obesity and metabolic comorbidities represent increasing health problems.
Endocrine disrupting compounds (EDCs) are exogenous agents that change endocrine function and cause adverse health effects.
Most EDCs are synthetic chemicals; some are natural food components as phytoestrogens.
People are exposed to complex mixtures of chemicals throughout their lives.
EDCs impact hormone-dependent metabolic systems and brain function.
Laboratory and human studies provide compelling evidence that human chemical contamination can play a role in obesity epidemic.
Chemical exposures may increase the risk of obesity by altering the differentiation of adipocytes.
EDCs can alter methylation patterns and normal epigenetic programming in cells.
Oxidative stress may be induced by many of these chemicals, and accumulating evidence indicates that it plays important roles in the etiology of chronic diseases.
The individual sensitivity to chemicals is variable, depending on environment and ability to metabolize hazardous chemicals.
A number of genes, especially those representing antioxidant and detoxification pathways, have potential application as biomarkers of risk assessment.
The potential health effects of combined exposures make the risk assessment process more complex compared to the assessment of single chemicals.
Techniques and methods need to be further developed to fill data gaps and increase the knowledge on harmful exposure combinations.
American Psychological Association (APA)
Lubrano, Carla& Genovesi, Giuseppe& Specchia, Palma& Costantini, Daniela& Mariani, Stefania& Petrangeli, Elisa…[et al.]. 2013. Obesity and Metabolic Comorbidities : Environmental Diseases?. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-487439
Modern Language Association (MLA)
Lubrano, Carla…[et al.]. Obesity and Metabolic Comorbidities : Environmental Diseases?. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-487439
American Medical Association (AMA)
Lubrano, Carla& Genovesi, Giuseppe& Specchia, Palma& Costantini, Daniela& Mariani, Stefania& Petrangeli, Elisa…[et al.]. Obesity and Metabolic Comorbidities : Environmental Diseases?. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-487439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487439