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The Phospholipid Profile of Mycoplasmas
Joint Authors
Rottem, Shlomo
Kornspan, Jonathan D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The de novo synthesized polar lipids of Mycoplasma species are rather simple, comprising primarily of the acidic glycerophospholipids PG and CL.
In addition, when grown in a medium containing serum, significant amounts of PC and SPM are incorporated into the mycoplasma cell membrane although these lipids are very uncommon in wall-covered bacteria.
The exogenous lipids are either incorporated unchanged or the PC incorporated is modified by a deacylation-acylation enzymatic cycle to form disaturated PC.
Although their small genome, in some Mycoplasma species, other genes involved in lipid biosynthesis were detected, resulting in the synthesis of a variety of glycolipis, phosphoglycolipids and ether lipids.
We suggest that analyses and comparisons of mycoplasma polar lipids may serve as a novel and useful tool for classification.
Nonetheless, to evaluate the importance of polar lipids in mycoplasma, further systematic and extensive studies on more Mycoplasma species are needed.
While studies are needed to elucidate the role of lipids in the mechanisms governing the interaction of mycoplasmas with host eukaryotic cells, the finding that a terminal phosphocholine containing glycolipids of M.
fermentans serves both as a major immune determinants and as a trigger of the inflammatory responses, and the findings that the fusogenicity of M.
fermentans with host cells is markedly stimulated by lyso-ether lipids, are important steps toward understanding the molecular mechanisms of M.
fermentans pathogenicity.
American Psychological Association (APA)
Kornspan, Jonathan D.& Rottem, Shlomo. 2012. The Phospholipid Profile of Mycoplasmas. Journal of Lipids،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487449
Modern Language Association (MLA)
Kornspan, Jonathan D.& Rottem, Shlomo. The Phospholipid Profile of Mycoplasmas. Journal of Lipids No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487449
American Medical Association (AMA)
Kornspan, Jonathan D.& Rottem, Shlomo. The Phospholipid Profile of Mycoplasmas. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487449