Identification and Quantification of Protein Glycosylation
Joint Authors
Yehezkel, Galit
Roth, Ziv
Khalaila, Isam
Source
International Journal of Carbohydrate Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glycosylation is one of the most abundant posttranslation modifications of proteins, and accumulating evidence indicate that the vast majority of proteins in eukaryotes are glycosylated.
Glycosylation plays a role in protein folding, interaction, stability, and mobility, as well as in signal transduction.
Thus, by regulating protein activity, glycosylation is involved in the normal functioning of the cell and in the development of diseases.
Indeed, in the past few decades there has been a growing realization of the importance of protein glycosylation, as aberrant glycosylation has been implicated in metabolic, neurodegenerative, and neoplastic diseases.
Thus, the identification and quantification of protein-borne oligosaccharides have become increasingly important both in the basic sciences of biochemistry and glycobiology and in the applicative sciences, particularly biomedicine and biotechnology.
Here, we review the state-of-the-art methodologies for the identification and quantification of oligosaccharides, specifically N- and O-glycosylated proteins.
American Psychological Association (APA)
Roth, Ziv& Yehezkel, Galit& Khalaila, Isam. 2012. Identification and Quantification of Protein Glycosylation. International Journal of Carbohydrate Chemistry،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487469
Modern Language Association (MLA)
Roth, Ziv…[et al.]. Identification and Quantification of Protein Glycosylation. International Journal of Carbohydrate Chemistry No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-487469
American Medical Association (AMA)
Roth, Ziv& Yehezkel, Galit& Khalaila, Isam. Identification and Quantification of Protein Glycosylation. International Journal of Carbohydrate Chemistry. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487469