Computational Prediction of Protein Function Based on Weighted Mapping of Domains and GO Terms
Joint Authors
Wang, Chunyu
Li, Jin
Dai, Qiguo
Liu, Xiaoyan
Guo, Maozu
Teng, Zhixia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this paper, we propose a novel method, SeekFun, to predict protein function based on weighted mapping of domains and GO terms.
Firstly, a weighted mapping of domains and GO terms is constructed according to GO annotations and domain composition of the proteins.
The association strength between domain and GO term is weighted by symmetrical conditional probability.
Secondly, the mapping is extended along the true paths of the terms based on GO hierarchy.
Finally, the terms associated with resident domains are transferred to host protein and real annotations of the host protein are determined by association strengths.
Our careful comparisons demonstrate that SeekFun outperforms the concerned methods on most occasions.
SeekFun provides a flexible and effective way for protein function prediction.
It benefits from the well-constructed mapping of domains and GO terms, as well as the reasonable strategy for inferring annotations of protein from those of its domains.
American Psychological Association (APA)
Teng, Zhixia& Guo, Maozu& Dai, Qiguo& Wang, Chunyu& Li, Jin& Liu, Xiaoyan. 2014. Computational Prediction of Protein Function Based on Weighted Mapping of Domains and GO Terms. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-487515
Modern Language Association (MLA)
Teng, Zhixia…[et al.]. Computational Prediction of Protein Function Based on Weighted Mapping of Domains and GO Terms. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-487515
American Medical Association (AMA)
Teng, Zhixia& Guo, Maozu& Dai, Qiguo& Wang, Chunyu& Li, Jin& Liu, Xiaoyan. Computational Prediction of Protein Function Based on Weighted Mapping of Domains and GO Terms. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-487515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487515