Evaluation of Mucoadhesive Gels with Propolis (EPP-AF) in Preclinical Treatment of Candidiasis Vulvovaginal Infection
Joint Authors
Bom, Vinícius Pedro
de Castro, Patrícia Alves
Ramalho, Leandra Naira Zambelli
Berretta, Andresa Aparecida
Pedrazzi, Vinícius
Goldman, Gustavo Henrique
Marquele-Oliveira, Franciane
Cavalheiro, Amanda Henriques
Rodrigues, Andresa Piacezzi Nascimento
Fortes, Vanessa Silveira
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-07
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Vulvovaginal candidiasis is the second cause of vaginal infection in the USA.
Clinical treatment of C.
albicans infections is routinely performed with polyenes and azole derivatives.
However, these drugs are responsible for undesirable side effects and toxicity.
In addition, C.
albicans azole and echinocandin resistance has been described.
Propolis is a bee product traditionally used due to its antimicrobial, anti-inflammatory, and other properties.
Therefore, the present work aimed to evaluate different propolis presentations in order to evaluate their in vitro and in vivo efficacy.
The methodologies involved antifungal evaluation, chemical analysis, and the effects of the rheological and mucoadhesive properties of propolis based gels.
The obtained results demonstrated the fungicide action of propolis extracts against all three morphotypes (yeast, pseudohyphae, and hyphae) studied.
The highest level of fungal cytotoxicity was reached at 6–8 hours of propolis cell incubation.
Among the based gel formulations developed, the rheological and mucoadhesive results suggest that propolis based carbopol (CP1%) and chitosan gels were the most pseudoplastic ones.
CP1% was the most mucoadhesive preparation, and all of them presented low thixotropy.
Results of in vivo efficacy demonstrated that propolis based gels present antifungal action similar to clotrimazole cream, suggesting that future clinical studies should be performed.
American Psychological Association (APA)
Berretta, Andresa Aparecida& de Castro, Patrícia Alves& Cavalheiro, Amanda Henriques& Fortes, Vanessa Silveira& Bom, Vinícius Pedro& Rodrigues, Andresa Piacezzi Nascimento…[et al.]. 2013. Evaluation of Mucoadhesive Gels with Propolis (EPP-AF) in Preclinical Treatment of Candidiasis Vulvovaginal Infection. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-487517
Modern Language Association (MLA)
Berretta, Andresa Aparecida…[et al.]. Evaluation of Mucoadhesive Gels with Propolis (EPP-AF) in Preclinical Treatment of Candidiasis Vulvovaginal Infection. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-487517
American Medical Association (AMA)
Berretta, Andresa Aparecida& de Castro, Patrícia Alves& Cavalheiro, Amanda Henriques& Fortes, Vanessa Silveira& Bom, Vinícius Pedro& Rodrigues, Andresa Piacezzi Nascimento…[et al.]. Evaluation of Mucoadhesive Gels with Propolis (EPP-AF) in Preclinical Treatment of Candidiasis Vulvovaginal Infection. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-487517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487517