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Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab
Joint Authors
Gonsalves, Wilson I.
Witzig, Thomas E.
Howard, Matthew T.
Smeltzer, Jacob P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Epstein-Barr virus (EBV) is a ubiquitous virus that commonly affects children and adolescents.
In addition to causing a viral illness, it is also associated with various malignancies in particular B cell lymphomas and lymphoproliferative disorders.
Differentiating between the two processes can be a diagnostic challenge.
Here, we present a case of an atypical EBV infection in an elderly patient with severe systemic symptoms, multiorgan involvement, lymphadenopathy, and negative EBV serology.
Excisional lymph node biopsy demonstrated features of a lymphoproliferative process involving EBV.
Despite supportive care, she experienced continued clinical deterioration and was successfully treated with rituximab.
This case illustrates the diagnostic challenges of these cases particularly in the elderly who may have age related immunosenescence, the utility of EBV PCR testing, and the clinical efficacy of rituximab in clearing the infected cells.
American Psychological Association (APA)
Smeltzer, Jacob P.& Howard, Matthew T.& Gonsalves, Wilson I.& Witzig, Thomas E.. 2014. Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-487518
Modern Language Association (MLA)
Smeltzer, Jacob P.…[et al.]. Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab. Case Reports in Hematology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-487518
American Medical Association (AMA)
Smeltzer, Jacob P.& Howard, Matthew T.& Gonsalves, Wilson I.& Witzig, Thomas E.. Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-487518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487518