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The Impact of Ly49-NK Cell-Dependent Recognition of MCMV Infection on Innate and Adaptive Immune Responses
Joint Authors
Vidal, Silvia M.
Pyzik, Michal
Gendron-Pontbriand, Eve-Marie
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Clinical and experimental data indicate that a subset of innate lymphocytes, natural killer (NK) cells, plays a crucial role in the response against herpesviruses, especially cytomegaloviruses (CMV).
Indeed, in mice, NK cells, due to the expression of germline encoded Ly49 receptors, possess multiple mechanisms to recognize CMV infection.
Classically, this results in NK cell activation and the destruction of the infected cells.
More recently, however, this unique host-pathogen interaction has permitted the discovery of novel aspects of NK cell biology, implicating them in the regulation of adaptive immune responses as well as in the development of immunological memory.
Here, we will concisely review the newly acquired evidence pertaining to NK cell Ly49-dependent recognition of MCMV-infected cell and the ensuing NK cell regulatory responses.
American Psychological Association (APA)
Pyzik, Michal& Gendron-Pontbriand, Eve-Marie& Vidal, Silvia M.. 2011. The Impact of Ly49-NK Cell-Dependent Recognition of MCMV Infection on Innate and Adaptive Immune Responses. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487544
Modern Language Association (MLA)
Pyzik, Michal…[et al.]. The Impact of Ly49-NK Cell-Dependent Recognition of MCMV Infection on Innate and Adaptive Immune Responses. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-487544
American Medical Association (AMA)
Pyzik, Michal& Gendron-Pontbriand, Eve-Marie& Vidal, Silvia M.. The Impact of Ly49-NK Cell-Dependent Recognition of MCMV Infection on Innate and Adaptive Immune Responses. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487544