ABO Blood Groups and Cardiovascular Diseases
Joint Authors
Mooney, Ciarán J.
Reilly, Muredach P.
Zhang, Hanrui
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
ABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases.
Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries.
There have been substantial historical associations between non-O blood group status and an increase in some cardiovascular disorders.
Recent GWASs have identified ABO as a locus for thrombosis, myocardial infarction, and multiple cardiovascular risk biomarkers, refocusing attention on mechanisms and potential for clinical advances.
As we highlight in this paper, more recent work is beginning to probe the molecular basis of the disease associations observed in these observational studies.
Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk.
The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases.
American Psychological Association (APA)
Zhang, Hanrui& Mooney, Ciarán J.& Reilly, Muredach P.. 2012. ABO Blood Groups and Cardiovascular Diseases. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-487556
Modern Language Association (MLA)
Zhang, Hanrui…[et al.]. ABO Blood Groups and Cardiovascular Diseases. International Journal of Vascular Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-487556
American Medical Association (AMA)
Zhang, Hanrui& Mooney, Ciarán J.& Reilly, Muredach P.. ABO Blood Groups and Cardiovascular Diseases. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-487556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487556