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Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan) Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation
Joint Authors
Rajaiah, Rajesh
Lee, David Y.-W.
Ma, Zhongze
Moudgil, Kamal D.
Yang, Ying-Hua
Berman, Brian
Lao, Lixing
Fong, Harry H. S.
Yu, Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is one of the major autoimmune diseases of global prevalence.
The use of the anti-inflammatory drugs for the treatment of RA is associated with severe adverse reactions and toxicity.
This limitation has necessitated the search for novel therapeutic products.
We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA) model.
HLXL (2.3 g/Kg) was fed to Lewis (RT.11) rats daily by gavage beginning at the onset of arthritis and then continued through the observation period.
HLXL inhibited the severity of ongoing AA.
This suppression of arthritis was associated with significant alterations in the T cell proliferative and cytokine responses as well as the antibody response against the disease-related antigen, mycobacterial heat-shock protein 65 (Bhsp65).
There was a reduction in the level of the proinflammatory cytokines IL-17 and IL-1β but enhancement of the anti-inflammatory cytokine IL-10 level.
In addition, there was inhibition of both the anti-Bhsp65 antibody response and the serum level of nitric oxide.
Thus, HLXL is a promising CAM modality for further testing in RA patients.
American Psychological Association (APA)
Yang, Ying-Hua& Rajaiah, Rajesh& Lee, David Y.-W.& Ma, Zhongze& Yu, Hua& Fong, Harry H. S.…[et al.]. 2010. Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan) Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-487561
Modern Language Association (MLA)
Yang, Ying-Hua…[et al.]. Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan) Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-487561
American Medical Association (AMA)
Yang, Ying-Hua& Rajaiah, Rajesh& Lee, David Y.-W.& Ma, Zhongze& Yu, Hua& Fong, Harry H. S.…[et al.]. Suppression of Ongoing Experimental Arthritis by a Chinese Herbal Formula (Huo-Luo-Xiao-Ling Dan) Involves Changes in Antigen-Induced Immunological and Biochemical Mediators of Inflammation. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-487561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487561