Additive Value of B-Type Natriuretic Peptide on Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated Myocardial SPECT in Patients with Normal Left Ventricular Systolic Function
Joint Authors
Cho, Young-Seok
Chae, In-Ho
Koo, Bon-Kwon
Park, Young-Bae
Sir, Jung-Ju
Oh, Byung-Hee
Kim, Hyo-Soo
Choi, Dong-Ju
Chung, Woo-Young
Source
Cardiology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We evaluated whether BNP has additive value to SPECT in patients with normal left ventricular (LV) systolic function.
Data from 224 consecutive patients who underwent rest 201Tl-dipyridamole stress 99mTc-sestamibi gated SPECT and coronary angiography due to chest pain were analyzed.
Patients with true positive SPECT showed significant higher BNP level than those with false positive defect (38.5 (19.0–79.8) versus 19.0 (9.3–35.8), P=.01).
Patients with true negative SPECT also showed significantly lower BNP level than those with false negative SPECT (39.0 (23.0–77.0) versus 22.0 (15.0–43.0), P=.002).
In multivariate analyses, elevated BNP level (using a cut-off value of 23.0 pg/mL) was the strongest and independent predictor of CAD in overall patients (OR 2.75, 95% CI: 1.50–5.023, P=.001) and patients with positive SPECT (OR 3.34, 95% CI: 1.51–7.37, P=.003).
The area under the receiver-operating characteristic curve for CAD in overall patients and patients with positive SPECT was 0.673 (95% CI: 0.603–0.743, P<.001) and 0.694 (95% CI: 0.602–0.786, P<.001), respectively.
This study suggests that BNP level has additive diagnostic value to SPECT findings in predicting CAD in patients with normal LV systolic function.
American Psychological Association (APA)
Sir, Jung-Ju& Cho, Young-Seok& Chung, Woo-Young& Koo, Bon-Kwon& Chae, In-Ho& Choi, Dong-Ju…[et al.]. 2010. Additive Value of B-Type Natriuretic Peptide on Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated Myocardial SPECT in Patients with Normal Left Ventricular Systolic Function. Cardiology Research and Practice،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-487565
Modern Language Association (MLA)
Sir, Jung-Ju…[et al.]. Additive Value of B-Type Natriuretic Peptide on Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated Myocardial SPECT in Patients with Normal Left Ventricular Systolic Function. Cardiology Research and Practice No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-487565
American Medical Association (AMA)
Sir, Jung-Ju& Cho, Young-Seok& Chung, Woo-Young& Koo, Bon-Kwon& Chae, In-Ho& Choi, Dong-Ju…[et al.]. Additive Value of B-Type Natriuretic Peptide on Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated Myocardial SPECT in Patients with Normal Left Ventricular Systolic Function. Cardiology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-487565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487565