Toll-Like Receptors as Novel Therapeutic Targets for Ovarian Cancer
Joint Authors
Benencia, Fabian
Pate, Michelle
Muccioli, Maria
Sprague, Leslee
Nandigam, Harika
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ovarian cancer (OC) is an aggressive disease that affects approximately 1 in 70 women and has a poor prognosis (<50%, 5-year survival rate), in part because it is often diagnosed at a late stage.
There are three main types of OC: neoplasms of surface epithelial, germ cell, or stromal origin, with surface epithelial tumors comprising about 80% of all OCs.
In addition to improving diagnostics, it is necessary to develop more effective treatments for epithelial-origin OC.
Here, we describe the paradoxical roles of toll-like receptor (TLR) signaling in the progression of cancer and discuss how its modulation may result in decreased tumor growth and metastasis via the attenuation of proangiogenic cytokines and potentiation of proapoptotic factors.
In particular, it has been found that TLR activity can behave like a “double-edged sword”, as its signaling pathways have been implicated as having both tumor-suppressive and tumor-promoting effects.
With particular emphasis on OC, we discuss the need to consider the signaling details of TLRs and associated proteins in the multiple cell types present in the tumor milieu to achieve safe and effective design of TLR-based cancer therapies.
American Psychological Association (APA)
Muccioli, Maria& Sprague, Leslee& Nandigam, Harika& Pate, Michelle& Benencia, Fabian. 2012. Toll-Like Receptors as Novel Therapeutic Targets for Ovarian Cancer. ISRN Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487574
Modern Language Association (MLA)
Muccioli, Maria…[et al.]. Toll-Like Receptors as Novel Therapeutic Targets for Ovarian Cancer. ISRN Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487574
American Medical Association (AMA)
Muccioli, Maria& Sprague, Leslee& Nandigam, Harika& Pate, Michelle& Benencia, Fabian. Toll-Like Receptors as Novel Therapeutic Targets for Ovarian Cancer. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487574