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Pathophysiology of Resistant Hypertension : The Role of Sympathetic Nervous System
Joint Authors
Tsioufis, Konstantinos P.
Kordalis, Athanasios
Papademetriou, Vasilios
Flessas, Dimitris
Stefanadis, Christodoulos
Tsiachris, Dimitris
Anastasopoulos, Ioannis
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Resistant hypertension (RH) is a powerful risk factor for cardiovascular morbidity and mortality.
Among the characteristics of patients with RH, obesity, obstructive sleep apnea, and aldosterone excess are covering a great area of the mosaic of RH phenotype.
Increased sympathetic nervous system (SNS) activity is present in all these underlying conditions, supporting its crucial role in the pathophysiology of antihypertensive treatment resistance.
Current clinical and experimental knowledge points towards an impact of several factors on SNS activation, namely, insulin resistance, adipokines, endothelial dysfunction, cyclic intermittent hypoxaemia, aldosterone effects on central nervous system, chemoreceptors, and baroreceptors dysregulation.
The further investigation and understanding of the mechanisms leading to SNS activation could reveal novel therapeutic targets and expand our treatment options in the challenging management of RH.
American Psychological Association (APA)
Tsioufis, Konstantinos P.& Kordalis, Athanasios& Flessas, Dimitris& Anastasopoulos, Ioannis& Tsiachris, Dimitris& Papademetriou, Vasilios…[et al.]. 2011. Pathophysiology of Resistant Hypertension : The Role of Sympathetic Nervous System. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487589
Modern Language Association (MLA)
Tsioufis, Konstantinos P.…[et al.]. Pathophysiology of Resistant Hypertension : The Role of Sympathetic Nervous System. International Journal of Hypertension No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-487589
American Medical Association (AMA)
Tsioufis, Konstantinos P.& Kordalis, Athanasios& Flessas, Dimitris& Anastasopoulos, Ioannis& Tsiachris, Dimitris& Papademetriou, Vasilios…[et al.]. Pathophysiology of Resistant Hypertension : The Role of Sympathetic Nervous System. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487589