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Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage
Joint Authors
Ulloa, Luis
Cai, Bolin
Deitch, Edwin A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The inflammatory responses in sepsis and hemorrhage remain a major cause of death.
Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms.
However, the recognition of inflammatory cytokines as a common lethal pathway has become consent.
Proinflammatory cytokines such as tumor necrosis factor (TNF) or high-mobility group box1 (HMGB1) are fanatically released and cause lethal multiorgan dysfunction.
Inhibition of these cytokines can prevent the inflammatory responses and organ damage.
In seeking potential anti-inflammatory strategies, we reported that ethyl pyruvate and alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonists effectively restrained cytokine production to provide therapeutic benefits in both experimental sepsis and hemorrhage.
Here, we review the inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes.
American Psychological Association (APA)
Cai, Bolin& Deitch, Edwin A.& Ulloa, Luis. 2010. Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487593
Modern Language Association (MLA)
Cai, Bolin…[et al.]. Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage. Mediators of Inflammation No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-487593
American Medical Association (AMA)
Cai, Bolin& Deitch, Edwin A.& Ulloa, Luis. Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487593