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Lipid Chaperones and Metabolic Inflammation
Joint Authors
Furuhashi, Masato
Ota, Hideki
Ishimura, Shutaro
Miura, Tetsuji
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Over the past decade, a large body of evidence has emerged demonstrating an integration of metabolic and immune response pathways.
It is now clear that obesity and associated disorders such as insulin resistance and type 2 diabetes are associated with a metabolically driven, low-grade, chronic inflammatory state, referred to as “metaflammation.” Several inflammatory cytokines as well as lipids and metabolic stress pathways can activate metaflammation, which targets metabolically critical organs and tissues including adipocytes and macrophages to adversely affect systemic homeostasis.
On the other hand, inside the cell, fatty acid-binding proteins (FABPs), a family of lipid chaperones, as well as endoplasmic reticulum (ER) stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation.
Here, we discuss the molecular and cellular basis of the roles of FABPs, especially FABP4 and FABP5, in metaflammation and related diseases including obesity, diabetes, and atherosclerosis.
American Psychological Association (APA)
Furuhashi, Masato& Ishimura, Shutaro& Ota, Hideki& Miura, Tetsuji. 2011. Lipid Chaperones and Metabolic Inflammation. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-487610
Modern Language Association (MLA)
Furuhashi, Masato…[et al.]. Lipid Chaperones and Metabolic Inflammation. International Journal of Inflammation No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-487610
American Medical Association (AMA)
Furuhashi, Masato& Ishimura, Shutaro& Ota, Hideki& Miura, Tetsuji. Lipid Chaperones and Metabolic Inflammation. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-487610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487610