Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex
Joint Authors
Santos, Diógenes Santiago
Medeiros, Patrícia Soares de Maria de
Ducati, Rodrigo Gay
da Silva, Luiz Hildebrando Pereira
Basso, Luiz Augusto
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Malaria continues to be a major cause of children's morbidity and mortality worldwide, causing nearly one million deaths annually.
The human malaria parasite, Plasmodium falciparum, synthesizes fatty acids employing the Type II fatty acid biosynthesis system (FAS II), unlike humans that rely on the Type I (FAS I) pathway.
The FAS II system elongates acyl fatty acid precursors of the cell membrane in Plasmodium.
Enoyl reductase (ENR) enzyme is a member of the FAS II system.
Here we present steady-state kinetics, pre-steady-state kinetics, and equilibrium fluorescence spectroscopy data that allowed proposal of P.
falciparum ENR (PfENR) enzyme mechanism.
Moreover, building on previous results, the present study also evaluates the PfENR inhibition by the pentacyano(isoniazid)ferrateII compound.
This inorganic complex represents a new class of lead compounds for the development of antimalarial agents focused on the inhibition of PfENR.
American Psychological Association (APA)
Medeiros, Patrícia Soares de Maria de& Ducati, Rodrigo Gay& Basso, Luiz Augusto& Santos, Diógenes Santiago& da Silva, Luiz Hildebrando Pereira. 2011. Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex. Enzyme Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-487620
Modern Language Association (MLA)
Medeiros, Patrícia Soares de Maria de…[et al.]. Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex. Enzyme Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-487620
American Medical Association (AMA)
Medeiros, Patrícia Soares de Maria de& Ducati, Rodrigo Gay& Basso, Luiz Augusto& Santos, Diógenes Santiago& da Silva, Luiz Hildebrando Pereira. Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-487620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487620