Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic Pancreatitis
Joint Authors
Moser, A. James
Bottino, Rita
Grupillo, Maria
Mazariegos, George
Bertera, Suzanne
Wijkstrom, Martin
Walsh, R. Matthew
Melvin, Patricia R.
Fung, John J.
Soltys, Kyle
Trucco, Massimo
Slivka, Adam
Gelrud, Andres
Humar, Abhinav
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic pancreatitis is an inflammatory disease of the pancreas that causes permanent changes in the function and structure of the pancreas.
It is most commonly a complication of cystic fibrosis or due to a genetic predisposition.
Chronic pancreatitis generally presents symptomatically as recurrent abdominal pain, which becomes persistent over time.
The pain eventually becomes disabling.
Once specific medical treatments and endoscopic interventions are no longer efficacious, total pancreatectomy is the alternative of choice for helping the patient achieve pain control.
While daily administrations of digestive enzymes cannot be avoided, insulin-dependent diabetes can be prevented by transplanting the isolated pancreatic islets back to the patient.
The greater the number of islets infused, the greater the chance to prevent or at least control the effects of surgical diabetes.
We present here a technical approach for the isolation and preservation of the islets proven to be efficient to obtain high numbers of islets, favoring the successful treatment of young patients.
American Psychological Association (APA)
Bottino, Rita& Bertera, Suzanne& Grupillo, Maria& Melvin, Patricia R.& Humar, Abhinav& Mazariegos, George…[et al.]. 2012. Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic Pancreatitis. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487622
Modern Language Association (MLA)
Bottino, Rita…[et al.]. Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic Pancreatitis. Journal of Transplantation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487622
American Medical Association (AMA)
Bottino, Rita& Bertera, Suzanne& Grupillo, Maria& Melvin, Patricia R.& Humar, Abhinav& Mazariegos, George…[et al.]. Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic Pancreatitis. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487622