Chondroitin Sulfate Proteoglycans : Structure-Function Relationship with Implication in Neural Development and Brain Disorders
Joint Authors
Shaposhnikov, Sergey
Mernea, Maria
Avram, Speranta
Buiu, Catalin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components that contain two structural parts with distinct functions: a protein core and glycosaminoglycan (GAG) side chains.
CSPGs are known to be involved in important cell processes like cell adhesion and growth, receptor binding, or cell migration.
It is recognized that the presence of CSPGs is critical in neuronal growth mechanisms including axon guidance following injury of nervous system components such as spinal cord and brain.
CSPGs are upregulated in the central nervous system after injury and participate in the inhibition of axon regeneration mainly through their GAG side chains.
Recently, it was shown that some CSPGs members like aggrecan, versican, and neurocan were strongly involved in brain disorders like bipolar disorder (BD), schizophrenia, and ADHD.
In this paper, we present the chemical structure-biological functions relationship of CSPGs, both in health state and in genetic disorders, addressing methods represented by genome-wide and crystallographic data as well as molecular modeling and quantitative structure-activity relationship.
American Psychological Association (APA)
Avram, Speranta& Shaposhnikov, Sergey& Buiu, Catalin& Mernea, Maria. 2014. Chondroitin Sulfate Proteoglycans : Structure-Function Relationship with Implication in Neural Development and Brain Disorders. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-487624
Modern Language Association (MLA)
Avram, Speranta…[et al.]. Chondroitin Sulfate Proteoglycans : Structure-Function Relationship with Implication in Neural Development and Brain Disorders. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-487624
American Medical Association (AMA)
Avram, Speranta& Shaposhnikov, Sergey& Buiu, Catalin& Mernea, Maria. Chondroitin Sulfate Proteoglycans : Structure-Function Relationship with Implication in Neural Development and Brain Disorders. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-487624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487624