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Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency
Joint Authors
Kraus, Teresa
Khawandanah, Mohamad
Cherry, Mohamad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cutaneous Hodgkin lymphoma is a rare condition.
Specific neoplastic involvement can be primary (confined to the skin) or secondary to systemic involvement (metastatic).
Cutaneous involvement by HL usually occurs late in the course and is associated with poor prognosis; however in some cases it can exhibit indolent behavior.
Skin involvement with nonspecific cutaneous findings may represent a paraneoplastic syndrome.
We describe a case of 46-year-old white male patient presented with rash and lymphadenopathy which led to the diagnosis of stage IVE mixed cellularity classical Hodgkin lymphoma with skin involvement.
His disease was refractory to multiple lines of chemotherapy including (1) AVD (doxorubicin/bleomycin/dacarbazine), (2) brentuximab, and (3) bendamustine, he later achieved complete remission with (4) GCD (gemcitabine/carboplatin/dexamethasone) salvage regimen.
Bleomycin was not given secondary to poor pulmonary function tests.
His treatment was complicated after AVD with multiple pneumothoraces which unmasked the diagnosis of ZZ phenotype alpha-1 antitrypsin (ATT) deficiency.
Simultaneous existence of Hodgkin lymphoma and ATT is rarely reported.
American Psychological Association (APA)
Khawandanah, Mohamad& Kraus, Teresa& Cherry, Mohamad. 2014. Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-487633
Modern Language Association (MLA)
Khawandanah, Mohamad…[et al.]. Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency. Case Reports in Hematology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-487633
American Medical Association (AMA)
Khawandanah, Mohamad& Kraus, Teresa& Cherry, Mohamad. Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-487633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487633