GERD—Barrett—Adenocarcinoma : Do We Have Suitable Prognostic and Predictive Molecular Markers?
Joint Authors
Illig, Romana
Neureiter, Daniel
Klieser, Eckhard
Kiesslich, Tobias
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Due to unfavorable lifestyle habits (unhealthy diet and tobacco abuse) the incidence of gastroesophageal reflux disease (GERD) in western countries is increasing.
The GERD-Barrett-Adenocarcinoma sequence currently lacks well-defined diagnostic, progressive, predictive, and prognostic biomarkers (i) providing an appropriate screening method identifying the presence of the disease, (ii) estimating the risk of evolving cancer, that is, the progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC), (iii) predicting the response to therapy, and (iv) indicating an overall survival—prognosis for EAC patients.
Based on histomorphological findings, detailed screening and therapeutic guidelines have been elaborated, although epidemiological studies could not support the postulated increasing progression rates of GERD to BE and EAC.
Additionally, proposed predictive and prognostic markers are rather heterogeneous by nature, lack substantial proofs, and currently do not allow stratification of GERD patients for progression, outcome, and therapeutic effectiveness in clinical practice.
The aim of this paper is to discuss the current knowledge regarding the GERD-BE-EAC sequence mainly focusing on the disputable and ambiguous status of proposed biomarkers to identify promising and reliable markers in order to provide more detailed insights into pathophysiological mechanisms and thus to improve prognostic and predictive therapeutic approaches.
American Psychological Association (APA)
Illig, Romana& Klieser, Eckhard& Kiesslich, Tobias& Neureiter, Daniel. 2013. GERD—Barrett—Adenocarcinoma : Do We Have Suitable Prognostic and Predictive Molecular Markers?. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487653
Modern Language Association (MLA)
Illig, Romana…[et al.]. GERD—Barrett—Adenocarcinoma : Do We Have Suitable Prognostic and Predictive Molecular Markers?. Gastroenterology Research and Practice No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-487653
American Medical Association (AMA)
Illig, Romana& Klieser, Eckhard& Kiesslich, Tobias& Neureiter, Daniel. GERD—Barrett—Adenocarcinoma : Do We Have Suitable Prognostic and Predictive Molecular Markers?. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487653