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External Validation of an Artificial Neural Network and Two Nomograms for Prostate Cancer Detection
Joint Authors
Ruttloff, Jürgen
Gerullis, Holger
Cammann, Henning
Ecke, Thorsten H.
Hallmann, Steffen
Miller, Kurt
Koch, Stefan
Stephan, Carsten
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Multivariate models are used to increase prostate cancer (PCa) detection rate and to reduce unnecessary biopsies.
An external validation of the artificial neural network (ANN) “ProstataClass” (ANN-Charité) was performed with daily routine data.
Materials and Methods.
The individual ANN predictions were generated with the use of the ANN application for PSA and free PSA assays, which rely on age, tPSA, %fPSA, prostate volume, and DRE (ANN-Charité).
Diagnostic validity of tPSA, %fPSA, and the ANN was evaluated by ROC curve analysis and comparisons of observed versus predicted probabilities.
Results.
Overall, 101 (35.8%) PCa were detected.
The areas under the ROC curve (AUCs) were 0.501 for tPSA, 0.669 for %fPSA, 0.694 for ANN-Charité, 0.713 for nomogram I, and 0.742 for nomogram II, showing a significant advantage for nomogram II (P=0.009) compared with %fPSA while the other model did not differ from %fPSA (P=0.15 and P=0.41).
All models overestimated the predicted PCa probability.
Conclusions.
Beside ROC analysis, calibration is an important tool to determine the true value of using a model in clinical practice.
The worth of multivariate models is limited when external validations were performed without knowledge of the circumstances of the model's development.
American Psychological Association (APA)
Ecke, Thorsten H.& Hallmann, Steffen& Koch, Stefan& Ruttloff, Jürgen& Cammann, Henning& Gerullis, Holger…[et al.]. 2012. External Validation of an Artificial Neural Network and Two Nomograms for Prostate Cancer Detection. ISRN Urology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487664
Modern Language Association (MLA)
Ecke, Thorsten H.…[et al.]. External Validation of an Artificial Neural Network and Two Nomograms for Prostate Cancer Detection. ISRN Urology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-487664
American Medical Association (AMA)
Ecke, Thorsten H.& Hallmann, Steffen& Koch, Stefan& Ruttloff, Jürgen& Cammann, Henning& Gerullis, Holger…[et al.]. External Validation of an Artificial Neural Network and Two Nomograms for Prostate Cancer Detection. ISRN Urology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487664