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The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy
Joint Authors
Campbell, Lynda J.
MacKinnon, Ruth N.
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Dicentric chromosomes have been identified as instigators of the genome instability associated with cancer, but this instability is often resolved by one of a number of different secondary events.
These include centromere inactivation, inversion, and intercentromeric deletion.
Deletion or excision of one of the centromeres may be a significant occurrence in myeloid malignancy and other malignancies but has not previously been widely recognized, and our reports are the first describing centromere deletion in cancer cells.
We review what is known about dicentric chromosomes and the mechanisms by which they can undergo stabilization in both constitutional and cancer genomes.
The failure to identify centromere deletion in cancer cells until recently can be partly explained by the standard approaches to routine diagnostic cancer genome analysis, which do not identify centromeres in the context of chromosome organization.
This hitherto hidden group of primary dicentric, secondary monocentric chromosomes, together with other unrecognized dicentric chromosomes, points to a greater role for dicentric chromosomes in cancer initiation and progression than is generally acknowledged.
We present a model that predicts and explains a significant role for dicentric chromosomes in the formation of unbalanced translocations in malignancy.
American Psychological Association (APA)
MacKinnon, Ruth N.& Campbell, Lynda J.. 2011. The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy. Genetics Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-487692
Modern Language Association (MLA)
MacKinnon, Ruth N.& Campbell, Lynda J.. The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy. Genetics Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-487692
American Medical Association (AMA)
MacKinnon, Ruth N.& Campbell, Lynda J.. The Role of Dicentric Chromosome Formation and Secondary Centromere Deletion in the Evolution of Myeloid Malignancy. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-487692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487692