The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions : A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives
Joint Authors
Quadrelli, Paolo
Mella, Mariella
Memeo, Misal Giuseppe
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Isoxazoline γ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to the N-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO4.
The reduction of the amide groups is easily conducted in the presence of LiAlH4 under mild conditions, which allowed for the chemoselective reduction of the amide moiety followed by ring opening to afford the desired conformationally locked isoxazoline-carbocyclic aminols, as valuable intermediates for nucleoside synthesis.
American Psychological Association (APA)
Memeo, Misal Giuseppe& Mella, Mariella& Quadrelli, Paolo. 2012. The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions : A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487695
Modern Language Association (MLA)
Memeo, Misal Giuseppe…[et al.]. The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions : A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-487695
American Medical Association (AMA)
Memeo, Misal Giuseppe& Mella, Mariella& Quadrelli, Paolo. The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions : A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487695