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Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract
Joint Authors
Verma, Preeti
Sharma, Priyanka
Goyal, P. K.
Sharma, Priyanka
Parmar, Jyoti
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The primary objective of this investigation is to determine the deleterious effects of sub lethal gamma radiation on testes and their possible inhibition by Tinospora cordifolia extract (TCE).
For this purpose, one group of male Swiss albino mice was exposed to 7.5 Gy gamma radiation to serve as the irradiated control, while the other group received TCE (75 mg/kg b. wt./day) orally for 5 consecutive days half an hr before irradiation to serve as experimental.
Exposure of animals to 7.5 Gy gamma radiation resulted into significant decrease in body weight, tissue weight, testes- body weight ratio and tubular diameter up to 15 days of irradiation.
Cent percent mortality was recorded by day 17th in irradiated control, whereas all animals survived in experimental group.
TCE pretreatment rendered significant increase in body weight, tissue weight, testes- body weight ratio and tubular diameter at various intervals as compared to irradiated group.
Radiation induced histological lesions in testicular architecture were observed more severe in irradiated control then the experimental.
TCE administration before irradiation significantly ameliorated radiation induced elevation in lipid peroxidation and decline in glutathione concentration in testes.
These observations indicate the radio- protective potential of Tinospora cordifolia root extract in testicular constituents against gamma irradiation in mice.
American Psychological Association (APA)
Sharma, Priyanka& Parmar, Jyoti& Sharma, Priyanka& Verma, Preeti& Goyal, P. K.. 2011. Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487719
Modern Language Association (MLA)
Sharma, Priyanka…[et al.]. Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-487719
American Medical Association (AMA)
Sharma, Priyanka& Parmar, Jyoti& Sharma, Priyanka& Verma, Preeti& Goyal, P. K.. Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-487719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487719