Relative Copy Number Variations of CYP2C19 in South Indian Population
Joint Authors
Rajagopal, Krishnamoorthy
Shewade, Deepak Gopal
Uppugunduri, Chakradhara Rao Satyanarayana
Chandrasekaran, Adithan
Sundaram, Rajan
Devendran, Anichavezhi
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
CYP2C19 is a polymorphic enzyme involved in the metabolism of clinically important drugs.
Genotype-phenotype association studies of CYP2C19 have reported wide ranges in the metabolic ratios of its substrates.
These discrepancies could be attributed to the variations in the promoter region and this aspect has been reported recently.
The observations in the recent reports on the influence of promoter region variants on the metabolism of CYP2C19 substrates might also have been influenced by the copy number variations of CYP2C19.
In this paper, we describe copy number variations of CYP2C19 using real-time polymerase chain reaction by comparative Ct method.
No copy number variations were observed in the south Indian population indicating the observed discrepancies in genotype-phenotype association studies might be due to the regulatory region polymorphisms as reported earlier.
American Psychological Association (APA)
Devendran, Anichavezhi& Uppugunduri, Chakradhara Rao Satyanarayana& Sundaram, Rajan& Shewade, Deepak Gopal& Rajagopal, Krishnamoorthy& Chandrasekaran, Adithan. 2012. Relative Copy Number Variations of CYP2C19 in South Indian Population. Molecular Biology International،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-487720
Modern Language Association (MLA)
Devendran, Anichavezhi…[et al.]. Relative Copy Number Variations of CYP2C19 in South Indian Population. Molecular Biology International No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-487720
American Medical Association (AMA)
Devendran, Anichavezhi& Uppugunduri, Chakradhara Rao Satyanarayana& Sundaram, Rajan& Shewade, Deepak Gopal& Rajagopal, Krishnamoorthy& Chandrasekaran, Adithan. Relative Copy Number Variations of CYP2C19 in South Indian Population. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-487720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487720