Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis
Joint Authors
Stallons, L. Jay
McGregor, W. Glenn
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A critical step in the transformation of cells to the malignant state of cancer is the induction of mutations in the DNA of cells damaged by genotoxic agents.
Translesion DNA synthesis (TLS) is the process by which cells copy DNA containing unrepaired damage that blocks progression of the replication fork.
The DNA polymerases that catalyze TLS in mammals have been the topic of intense investigation over the last decade.
DNA polymerase η (Pol η) is best understood and is active in error-free bypass of UV-induced DNA damage.
The other TLS polymerases (Pol ι, Pol κ, REV1, and Pol ζ) have been studied extensively in vitro, but their in vivo role is only now being investigated using knockout mouse models of carcinogenesis.
This paper will focus on the studies of mice and humans with altered expression of TLS polymerases and the effects on cancer induced by environmental agents.
American Psychological Association (APA)
Stallons, L. Jay& McGregor, W. Glenn. 2010. Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487721
Modern Language Association (MLA)
Stallons, L. Jay& McGregor, W. Glenn. Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis. Journal of Nucleic Acids No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-487721
American Medical Association (AMA)
Stallons, L. Jay& McGregor, W. Glenn. Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487721