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MACT : A Manageable Minimization Allocation System
Joint Authors
Bu, Huaien
Cui, Yan
Wang, Hongwu
Liao, Shizhong
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Minimization is a case allocation method for randomized controlled trials (RCT).
Evidence suggests that the minimization method achieves balanced groups with respect to numbers and participant characteristics, and can incorporate more prognostic factors compared to other randomization methods.
Although several automatic allocation systems exist (e.g., randoWeb, and MagMin), the minimization method is still difficult to implement, and RCTs seldom employ minimization.
Therefore, we developed the minimization allocation controlled trials (MACT) system, a generic manageable minimization allocation system.
System Outline.
The MACT system implements minimization allocation by Web and email.
It has a unified interface that manages trials, participants, and allocation.
It simultaneously supports multitrials, multicenters, multigrouping, multiple prognostic factors, and multilevels.
Methods.
Unlike previous systems, MACT utilizes an optimized database that greatly improves manageability.
Simulations and Results.
MACT was assessed in a series of experiments and evaluations.
Relative to simple randomization, minimization produces better balance among groups and similar unpredictability.
Applications.
MACT has been employed in two RCTs that lasted three years.
During this period, MACT steadily and simultaneously satisfied the requirements of the trial.
Conclusions.
MACT is a manageable, easy-to-use case allocation system.
Its outstanding features are attracting more RCTs to use the minimization allocation method.
American Psychological Association (APA)
Cui, Yan& Bu, Huaien& Wang, Hongwu& Liao, Shizhong. 2014. MACT : A Manageable Minimization Allocation System. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-487742
Modern Language Association (MLA)
Cui, Yan…[et al.]. MACT : A Manageable Minimization Allocation System. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-487742
American Medical Association (AMA)
Cui, Yan& Bu, Huaien& Wang, Hongwu& Liao, Shizhong. MACT : A Manageable Minimization Allocation System. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-487742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487742