β-Glucan Oligosaccharide Enhances CD8+ T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen
Joint Authors
Wang, Yuan
Gu, Jianxin
Boraschi, Diana
Wang, Wei
Wang, Jing
Qu, Di
Sun, Shuhui
Liu, Chunhong
Dong, Shengfu
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
DNA vaccination can induce specific CD8+ T cell immune response, but the response level is low in large mammals and human beings.
Coadministration of an adjuvant can optimize protective immunity elicited by a DNA vaccine.
In this study, we investigated the effect of a synthetic glucohexaose (β-glu6), an analogue of Lentinan basic unit, on specific CD8+ T cell response induced by a DNA vaccine encoding HBcAg (pB144) in mice.
We found that β-glu6 promoted the recruitment and maturation of dendritic cells, enhanced the activation of CD8+ and CD4+ T cells and increased the number of specific CD8+/IFN-γ+ T cells in lymphoid and nonlymphoid tissues in mice immunized by pB144.
Immunization with pB144 and β-glu6 increased the anti-HBc IgG and IgG2a antibody titer.
These results demonstrate that β-glu6 can enhance the virus-specific CTL and Th1 responses induced by DNA vaccine, suggesting β-glu6 as a candidate adjuvant in DNA vaccination.
American Psychological Association (APA)
Wang, Jing& Dong, Shengfu& Liu, Chunhong& Wang, Wei& Sun, Shuhui& Gu, Jianxin…[et al.]. 2010. β-Glucan Oligosaccharide Enhances CD8+ T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487761
Modern Language Association (MLA)
Wang, Jing…[et al.]. β-Glucan Oligosaccharide Enhances CD8+ T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-487761
American Medical Association (AMA)
Wang, Jing& Dong, Shengfu& Liu, Chunhong& Wang, Wei& Sun, Shuhui& Gu, Jianxin…[et al.]. β-Glucan Oligosaccharide Enhances CD8+ T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487761