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Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin α6 in Human Breast Carcinoma Cells : A Downstream Modulator of TSP-1-Induced Cellular Adhesion
Joint Authors
Rothman, Vicki L.
John, Anitha S.
Tuszynski, George P.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Thrombospondin-1 (TSP-1) is involved in a variety of different cellular processes including cell adhesion, tumor progression, and angiogenesis.
This paper reports the novel finding that TSP-1 upregulates integrin α6 subunit in human keratinocytes and human breast cancer cells resulting in increased cell adhesion and tumor cell invasion.
The effect of TSP-1 on α6 subunit expression was examined in human keratinocytes and breast adenocarcinoma cell lines (MDA-MB-231) treated with TSP-1 and in TSP-1 stably transfected breast cancer cells.
TSP-1 upregulated α6 message and protein in these cells as revealed by differential display, Northern and Western blot analysis and immunohistochemical localization studies.
The increased expression of α6 was shown to mediate adhesion and invasion of these cells to laminin, a major component of the basement membrane and extracellular matrix (ECM).
These data suggest that TSP-1 plays an integral role in the attachment of cells to the ECM facilitating cell motility and angiogenesis.
American Psychological Association (APA)
John, Anitha S.& Rothman, Vicki L.& Tuszynski, George P.. 2010. Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin α6 in Human Breast Carcinoma Cells : A Downstream Modulator of TSP-1-Induced Cellular Adhesion. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487780
Modern Language Association (MLA)
John, Anitha S.…[et al.]. Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin α6 in Human Breast Carcinoma Cells : A Downstream Modulator of TSP-1-Induced Cellular Adhesion. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-487780
American Medical Association (AMA)
John, Anitha S.& Rothman, Vicki L.& Tuszynski, George P.. Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin α6 in Human Breast Carcinoma Cells : A Downstream Modulator of TSP-1-Induced Cellular Adhesion. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-487780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487780