Effects of Copper andor Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration
Joint Authors
Marra, Carlos A.
Castillo, Omar
Arnal, Nathalie
de Alaniz, María J. T.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Copper (Cu) and cholesterol (Cho) are both associated with neurodegenerative illnesses in humans and animals models.
We studied the effect in Wistar rats of oral supplementation with trace amounts of Cu (3 ppm) and/or Cho (2%) in drinking water for 2 months.
Increased amounts of nonceruloplasmin-bound Cu were observed in plasma and brain hippocampus together with a higher concentration of ceruloplasmin in plasma, cortex, and hippocampus.
Cu, Cho, and the combined treatment Cu + Cho were able to induce a higher Cho/phospholipid ratio in mitochondrial membranes with a simultaneous decrease in glutathione content.
The concentration of cardiolipin decreased and that of peroxidation products, conjugated dienes and lipoperoxides, increased.
Treatments including Cho produced rigidization in both the outer and inner mitochondrial membranes with a simultaneous increase in permeability.
No significant increase in Cyt C leakage to the cytosol was observed except in the case of cortex from rats treated with Cu and Cho nor were there any significant changes in caspase-3 activity and the Bax/Bcl2 ratio.
However, the Aβ(1–42)/(1–40) ratio was higher in cortex and hippocampus.
These findings suggest an incipient neurodegenerative process induced by Cu or Cho that might be potentiated by the association of the two supplements.
American Psychological Association (APA)
Arnal, Nathalie& Castillo, Omar& de Alaniz, María J. T.& Marra, Carlos A.. 2013. Effects of Copper andor Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration. Journal of Oncology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487781
Modern Language Association (MLA)
Arnal, Nathalie…[et al.]. Effects of Copper andor Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration. Journal of Oncology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-487781
American Medical Association (AMA)
Arnal, Nathalie& Castillo, Omar& de Alaniz, María J. T.& Marra, Carlos A.. Effects of Copper andor Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487781