Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients
Joint Authors
Myśliwska, Jolanta
Ryba-Stanisławowska, Monika
Rybarczyk-Kapturska, Karolina
Myśliwiec, Małgorzata
Zorena, Katarzyna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetes type 1 is a chronic autoimmune disease in which insulin-producing cells are gradually destroyed by autoreactive T cells.
Human regulatory cells play important role in controlling autoimmunity, and their qualitative or quantitative dysfunctions may result in ineffective suppression of autoreactive T cells.
CD62L is a surface molecule that plays role in homing capabilities of Tregs, and only cells with high expression of CD62L have high suppressive potential.
Tregs are also characterized by the constant expression of TNFR2.
The frequency of Tregs carrying TNFR2 is higher in inflammatory conditions.
We investigated blood regulatory T cells with CD62L expression and regulatory T cells expressing TNFR2 in type 1 diabetic patients.
We found differences in these populations when comparing to healthy individuals.
We propose that these may be associated with inflammatory conditions that are present in patients with type 1 diabetes.
The lower percentage of Tregs and Treg CD62Lhigh may contribute to ineffective suppression of proinflammatory cytokines production during type 1 diabetes.
American Psychological Association (APA)
Ryba-Stanisławowska, Monika& Rybarczyk-Kapturska, Karolina& Zorena, Katarzyna& Myśliwiec, Małgorzata& Myśliwska, Jolanta. 2011. Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487795
Modern Language Association (MLA)
Ryba-Stanisławowska, Monika…[et al.]. Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients. Mediators of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-487795
American Medical Association (AMA)
Ryba-Stanisławowska, Monika& Rybarczyk-Kapturska, Karolina& Zorena, Katarzyna& Myśliwiec, Małgorzata& Myśliwska, Jolanta. Lower Frequency of CD62Lhigh and Higher Frequency of TNFR2+ Tregs Are Associated with Inflammatory Conditions in Type 1 Diabetic Patients. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487795