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A Patient-Specific Airway Branching Model for Mechanically Ventilated Patients
Joint Authors
van Drunen, Erwin J.
Damanhuri, Nor Salwa
Docherty, Paul D.
Desaive, Thomas
Chase, J. Geoffrey
Chiew, Yeong Shiong
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Respiratory mechanics models have the potential to guide mechanical ventilation.
Airway branching models (ABMs) were developed from classical fluid mechanics models but do not provide accurate models of in vivo behaviour.
Hence, the ABM was improved to include patient-specific parameters and better model observed behaviour (ABMps).
Methods.
The airway pressure drop of the ABMps was compared with the well-accepted dynostatic algorithm (DSA) in patients diagnosed with acute respiratory distress syndrome (ARDS).
A scaling factor (α) was used to equate the area under the pressure curve (AUC) from the ABMps to the AUC of the DSA and was linked to patient state.
Results.
The ABMps recorded a median α value of 0.58 (IQR: 0.54–0.63; range: 0.45–0.66) for these ARDS patients.
Significantly lower α values were found for individuals with chronic obstructive pulmonary disease (P<0.001).
Conclusion.
The ABMps model allows the estimation of airway pressure drop at each bronchial generation with patient-specific physiological measurements and can be generated from data measured at the bedside.
The distribution of patient-specific α values indicates that the overall ABM can be readily improved to better match observed data and capture patient condition.
American Psychological Association (APA)
Damanhuri, Nor Salwa& Docherty, Paul D.& Chiew, Yeong Shiong& van Drunen, Erwin J.& Desaive, Thomas& Chase, J. Geoffrey. 2014. A Patient-Specific Airway Branching Model for Mechanically Ventilated Patients. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-487802
Modern Language Association (MLA)
Damanhuri, Nor Salwa…[et al.]. A Patient-Specific Airway Branching Model for Mechanically Ventilated Patients. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-487802
American Medical Association (AMA)
Damanhuri, Nor Salwa& Docherty, Paul D.& Chiew, Yeong Shiong& van Drunen, Erwin J.& Desaive, Thomas& Chase, J. Geoffrey. A Patient-Specific Airway Branching Model for Mechanically Ventilated Patients. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-487802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487802