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Oxidative Stress, Mitochondrial Dysfunction, and Aging
Joint Authors
Zhang, Hong
Cui, Hang
Kong, Yahui
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aging is an intricate phenomenon characterized by progressive decline in physiological functions and increase in mortality that is often accompanied by many pathological diseases.
Although aging is almost universally conserved among all organisms, the underlying molecular mechanisms of aging remain largely elusive.
Many theories of aging have been proposed, including the free-radical and mitochondrial theories of aging.
Both theories speculate that cumulative damage to mitochondria and mitochondrial DNA (mtDNA) caused by reactive oxygen species (ROS) is one of the causes of aging.
Oxidative damage affects replication and transcription of mtDNA and results in a decline in mitochondrial function which in turn leads to enhanced ROS production and further damage to mtDNA.
In this paper, we will present the current understanding of the interplay between ROS and mitochondria and will discuss their potential impact on aging and age-related diseases.
American Psychological Association (APA)
Cui, Hang& Kong, Yahui& Zhang, Hong. 2011. Oxidative Stress, Mitochondrial Dysfunction, and Aging. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-487857
Modern Language Association (MLA)
Cui, Hang…[et al.]. Oxidative Stress, Mitochondrial Dysfunction, and Aging. Journal of Signal Transduction No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-487857
American Medical Association (AMA)
Cui, Hang& Kong, Yahui& Zhang, Hong. Oxidative Stress, Mitochondrial Dysfunction, and Aging. Journal of Signal Transduction. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-487857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487857