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Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALIARDS
Joint Authors
Zuiderveen, Sandra
Hassan, Nabil
Sanfilippo, Dominic
Stoiko, Michael
Shoemaker, Allen
Curtis, Scott
Ndika, Akunne
Rajasekaran, Surender
Source
Critical Care Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery.
Hypothesis.
We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome.
The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children’s Hospital between January 1st 2008 and December 31st 2009.
Results.
Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control.
P/F ratio decreased from 135.4±7.5 to 116.5±8.8 in transfused but increased from 148.0±8.0 to 190.4±17.8 (P<0.001) in control.
OI increased in the transfused from 11.7±0.9 to 18.7±1.6 but not in control.
Ventilator days in the transfused were 15.6±1.7 versus 9.5±0.6 days in control (P<0.001).
There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6–5.6 Fisher exact P<0.282.
Conclusion.
This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs.
American Psychological Association (APA)
Rajasekaran, Surender& Sanfilippo, Dominic& Shoemaker, Allen& Curtis, Scott& Zuiderveen, Sandra& Ndika, Akunne…[et al.]. 2012. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALIARDS. Critical Care Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487865
Modern Language Association (MLA)
Rajasekaran, Surender…[et al.]. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALIARDS. Critical Care Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-487865
American Medical Association (AMA)
Rajasekaran, Surender& Sanfilippo, Dominic& Shoemaker, Allen& Curtis, Scott& Zuiderveen, Sandra& Ndika, Akunne…[et al.]. Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALIARDS. Critical Care Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487865