On Programmed Cell Death in Plasmodium falciparum : Status Quo
Joint Authors
Engelbrecht, Dewaldt
Durand, Pierre Marcel
Coetzer, Thérèsa Louise
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Conflicting arguments and results exist regarding the occurrence and phenotype of programmed cell death (PCD) in the malaria parasite Plasmodium falciparum.
Inconsistencies relate mainly to the number and type of PCD markers assessed and the different methodologies used in the studies.
In this paper, we provide a comprehensive overview of the current state of knowledge and empirical evidence for PCD in the intraerythrocytic stages of P.
falciparum.
We consider possible reasons for discrepancies in the data and offer suggestions towards more standardised investigation methods in this field.
Furthermore, we present genomic evidence for PCD machinery in P.
falciparum.
We discuss the potential adaptive or nonadaptive role of PCD in the parasite life cycle and its possible exploitation in the development of novel drug targets.
Lastly, we pose pertinent unanswered questions concerning the PCD phenomenon in P.
falciparum to provide future direction.
American Psychological Association (APA)
Engelbrecht, Dewaldt& Durand, Pierre Marcel& Coetzer, Thérèsa Louise. 2012. On Programmed Cell Death in Plasmodium falciparum : Status Quo. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-487874
Modern Language Association (MLA)
Engelbrecht, Dewaldt…[et al.]. On Programmed Cell Death in Plasmodium falciparum : Status Quo. Journal of Tropical Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-487874
American Medical Association (AMA)
Engelbrecht, Dewaldt& Durand, Pierre Marcel& Coetzer, Thérèsa Louise. On Programmed Cell Death in Plasmodium falciparum : Status Quo. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-487874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487874