Reflux Revisited : Advancing the Role of Pepsin
Joint Authors
Dettmar, Peter W.
Bardhan, Karna Dev
Strugala, Vicki
Source
International Journal of Otolaryngology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Gastroesophageal reflux disease is mediated principally by acid.
Today, we recognise reflux reaches beyond the esophagus, where pepsin, not acid, causes damage.
Extraesophageal reflux occurs both as liquid and probably aerosol, the latter with a further reach.
Pepsin is stable up to pH 7 and regains activity after reacidification.
The enzyme adheres to laryngeal cells, depletes its defences, and causes further damage internally after its endocytosis.
Extraesophageal reflux can today be detected by recognising pharyngeal acidification using a miniaturised pH probe and by the identification of pepsin in saliva and in exhaled breath condensate by a rapid, sensitive, and specific immunoassay.
Proton pump inhibitors do not help the majority with extraesophageal reflux but specifically formulated alginates, which sieve pepsin, give benefit.
These new insights may lead to the development of novel drugs that dramatically reduce pepsinogen secretion, block the effects of adherent pepsin, and give corresponding clinical benefit.
American Psychological Association (APA)
Bardhan, Karna Dev& Strugala, Vicki& Dettmar, Peter W.. 2011. Reflux Revisited : Advancing the Role of Pepsin. International Journal of Otolaryngology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-487892
Modern Language Association (MLA)
Bardhan, Karna Dev…[et al.]. Reflux Revisited : Advancing the Role of Pepsin. International Journal of Otolaryngology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-487892
American Medical Association (AMA)
Bardhan, Karna Dev& Strugala, Vicki& Dettmar, Peter W.. Reflux Revisited : Advancing the Role of Pepsin. International Journal of Otolaryngology. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-487892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487892