Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease

Joint Authors

Dunn, Sarah
Stephen, Sam L.
Freestone, Katie
Wheatcroft, Stephen B.
Walker, John H.
Twigg, Michael W.
Ponnambalam, Sreenivasan
Homer-Vanniasinkam, Shervanthi

Source

International Journal of Hypertension

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-21, 21 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-08-17

Country of Publication

Egypt

No. of Pages

21

Main Subjects

Diseases
Medicine

Abstract EN

Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens.

This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of atherosclerotic plaques.

In vascular tissues, scavenger receptors are implicated in regulating intracellular signaling, lipid accumulation, foam cell development, and cellular apoptosis or necrosis linked to the pathophysiology of atherosclerosis.

One approach is using gene therapy to modulate scavenger receptor function in atherosclerosis.

Ectopic expression of membrane-bound scavenger receptors using viral vectors can modify lipid profiles and reduce the incidence of atherosclerosis.

Alternatively, expression of soluble scavenger receptors can also block plaque initiation and progression.

Inhibition of scavenger receptor expression using a combined gene therapy and RNA interference strategy also holds promise for long-term therapy.

Here we review our current understanding of the gene delivery by viral vectors to cells and tissues in gene therapy strategies and its application to the modulation of scavenger receptor function in atherosclerosis.

American Psychological Association (APA)

Stephen, Sam L.& Freestone, Katie& Dunn, Sarah& Twigg, Michael W.& Homer-Vanniasinkam, Shervanthi& Walker, John H.…[et al.]. 2010. Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-487895

Modern Language Association (MLA)

Stephen, Sam L.…[et al.]. Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease. International Journal of Hypertension No. 2010 (2010), pp.1-21.
https://search.emarefa.net/detail/BIM-487895

American Medical Association (AMA)

Stephen, Sam L.& Freestone, Katie& Dunn, Sarah& Twigg, Michael W.& Homer-Vanniasinkam, Shervanthi& Walker, John H.…[et al.]. Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-487895

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-487895