Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease
Joint Authors
Dunn, Sarah
Stephen, Sam L.
Freestone, Katie
Wheatcroft, Stephen B.
Walker, John H.
Twigg, Michael W.
Ponnambalam, Sreenivasan
Homer-Vanniasinkam, Shervanthi
Source
International Journal of Hypertension
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-17
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens.
This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of atherosclerotic plaques.
In vascular tissues, scavenger receptors are implicated in regulating intracellular signaling, lipid accumulation, foam cell development, and cellular apoptosis or necrosis linked to the pathophysiology of atherosclerosis.
One approach is using gene therapy to modulate scavenger receptor function in atherosclerosis.
Ectopic expression of membrane-bound scavenger receptors using viral vectors can modify lipid profiles and reduce the incidence of atherosclerosis.
Alternatively, expression of soluble scavenger receptors can also block plaque initiation and progression.
Inhibition of scavenger receptor expression using a combined gene therapy and RNA interference strategy also holds promise for long-term therapy.
Here we review our current understanding of the gene delivery by viral vectors to cells and tissues in gene therapy strategies and its application to the modulation of scavenger receptor function in atherosclerosis.
American Psychological Association (APA)
Stephen, Sam L.& Freestone, Katie& Dunn, Sarah& Twigg, Michael W.& Homer-Vanniasinkam, Shervanthi& Walker, John H.…[et al.]. 2010. Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-487895
Modern Language Association (MLA)
Stephen, Sam L.…[et al.]. Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease. International Journal of Hypertension No. 2010 (2010), pp.1-21.
https://search.emarefa.net/detail/BIM-487895
American Medical Association (AMA)
Stephen, Sam L.& Freestone, Katie& Dunn, Sarah& Twigg, Michael W.& Homer-Vanniasinkam, Shervanthi& Walker, John H.…[et al.]. Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-487895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487895