Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats
Joint Authors
Xia, Liulu
Cai, Qian
Liang, Wenjia
Liu, Yi
Wan, Jiangbo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this paper, we established a delayed wound healing model on diabetic rat to mimic the pathophysiology of clinical patients who suffered from diabetic foot ulcers.
We also evaluated if transplantation of allogeneic bone marrow-derived mesenchymal stem cells could promote the delayed wound healing and investigated the possible underlying biological mechanisms and stem cell behavior involved in this process.
The results showed that bone marrow-derived mesenchymal stem cells had a positive effect on delayed wound healing in diabetic rats.
Intramuscular transplantation demonstrated the best efficacy.
This effect is associated with granulation tissue formation, angiogenesis, cellular proliferation, and high vascular endothelial growth factor expression in wound tissues.
In addition, bone marrow-derived mesenchymal stem cells have been shown to mobilize and find home for ischemic and wounded tissues to participate in the process of wound healing.
Intramuscular transplantation of exogenous isogeneic stem cells may be suitable for clinical application in the treatment of diabetic foot ulcers although the safety of this therapy should be considered.
American Psychological Association (APA)
Wan, Jiangbo& Xia, Liulu& Liang, Wenjia& Liu, Yi& Cai, Qian. 2013. Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-487904
Modern Language Association (MLA)
Wan, Jiangbo…[et al.]. Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats. Journal of Diabetes Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-487904
American Medical Association (AMA)
Wan, Jiangbo& Xia, Liulu& Liang, Wenjia& Liu, Yi& Cai, Qian. Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-487904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487904