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Potential Role of Garcinol as an Anticancer Agent
Joint Authors
Gupta, Smiti Vaid
Saadat, Nadia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Garcinol, a polyisoprenylated benzophenone, is extracted from the rind of the fruit of Garcinia indica, a plant found extensively in tropical regions.
Although the fruit has been consumed traditionally over centuries, its biological activities, specifically its anticancer potential is a result of recent scientific investigations.
The anticarcinogenic properties of garcinol appear to be moderated via its antioxidative, anti-inflammatory, antiangiogenic, and proapoptotic activities.
In addition, garcinol displays effective epigenetic influence by inhibiting histone acetyltransferases (HAT 300) and by possible posttranscriptional modulation by mi RNA profiles involved in carcinogenesis.
In vitro as well as some in vivo studies have shown the potential of this compound against several cancers types including breast, colon, pancreatic, and leukemia.
Although this is a promising molecule in terms of its anticancer properties, investigations in relevant animal models, and subsequent human trials are warranted in order to fully appreciate and confirm its chemopreventative and/or therapeutic potential.
American Psychological Association (APA)
Saadat, Nadia& Gupta, Smiti Vaid. 2012. Potential Role of Garcinol as an Anticancer Agent. Journal of Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487917
Modern Language Association (MLA)
Saadat, Nadia& Gupta, Smiti Vaid. Potential Role of Garcinol as an Anticancer Agent. Journal of Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487917
American Medical Association (AMA)
Saadat, Nadia& Gupta, Smiti Vaid. Potential Role of Garcinol as an Anticancer Agent. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487917
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487917