Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement
Joint Authors
Karsani, Saiful Anuar
Ellias, Mohd Faiz
Megat Abdul Wahab, Rohaya
Senafi, Shahidan
Abdul Rahman, Mariati
Zainal Ariffin, Shahrul Hisham
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Orthodontic treatment has been shown to induce inflammation, followed by bone remodelling in the periodontium.
These processes trigger the secretion of various proteins and enzymes into the saliva.
This study aims to identify salivary proteins that change in expression during orthodontic tooth movement.
These differentially expressed proteins can potentially serve as protein biomarkers for the monitoring of orthodontic treatment and tooth movement.
Whole saliva from three healthy female subjects were collected before force application using fixed appliance and at 14 days after 0.014′′ Niti wire was applied.
Salivary proteins were resolved using two-dimensional gel electrophoresis (2DE) over a pH range of 3–10, and the resulting proteome profiles were compared.
Differentially expressed protein spots were then identified by MALDI-TOF/TOF tandem mass spectrometry.
Nine proteins were found to be differentially expressed; however, only eight were identified by MALDI-TOF/TOF.
Four of these proteins—Protein S100-A9, immunoglobulin J chain, Ig alpha-1 chain C region, and CRISP-3—have known roles in inflammation and bone resorption.
American Psychological Association (APA)
Ellias, Mohd Faiz& Zainal Ariffin, Shahrul Hisham& Karsani, Saiful Anuar& Abdul Rahman, Mariati& Senafi, Shahidan& Megat Abdul Wahab, Rohaya. 2012. Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487921
Modern Language Association (MLA)
Ellias, Mohd Faiz…[et al.]. Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-487921
American Medical Association (AMA)
Ellias, Mohd Faiz& Zainal Ariffin, Shahrul Hisham& Karsani, Saiful Anuar& Abdul Rahman, Mariati& Senafi, Shahidan& Megat Abdul Wahab, Rohaya. Proteomic Analysis of Saliva Identifies Potential Biomarkers for Orthodontic Tooth Movement. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-487921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487921