Self-Organization of Motor-Propelled Cytoskeletal Filaments at Topographically Defined Borders
Joint Authors
Sundberg, Mark
Bunk, Richard
Montelius, Lars
Månsson, Alf
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Self-organization phenomena are of critical importance in living organisms and of great interest to exploit in nanotechnology.
Here we describe in vitro self-organization of molecular motor-propelled actin filaments, manifested as a tendency of the filaments to accumulate in high density close to topographically defined edges on nano- and microstructured surfaces.
We hypothesized that this “edge-tracing” effect either (1) results from increased motor density along the guiding edges or (2) is a direct consequence of the asymmetric constraints on stochastic changes in filament sliding direction imposed by the edges.
The latter hypothesis is well captured by a model explicitly defining the constraints of motility on structured surfaces in combination with Monte-Carlo simulations [cf.
Nitta et al.
(2006)] of filament sliding.
In support of hypothesis 2 we found that the model reproduced the edge tracing effect without the need to assume increased motor density at the edges.
We then used model simulations to elucidate mechanistic details.
The results are discussed in relation to nanotechnological applications and future experiments to test model predictions.
American Psychological Association (APA)
Månsson, Alf& Bunk, Richard& Sundberg, Mark& Montelius, Lars. 2012. Self-Organization of Motor-Propelled Cytoskeletal Filaments at Topographically Defined Borders. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487925
Modern Language Association (MLA)
Månsson, Alf…[et al.]. Self-Organization of Motor-Propelled Cytoskeletal Filaments at Topographically Defined Borders. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-487925
American Medical Association (AMA)
Månsson, Alf& Bunk, Richard& Sundberg, Mark& Montelius, Lars. Self-Organization of Motor-Propelled Cytoskeletal Filaments at Topographically Defined Borders. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487925